Product Data Sheet
NH2-PEG1-Val-Cit-PAB-OH
Catalog No. A43420
NH2-PEG1-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker designed for efficient payload delivery. This reagent features a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group, enabling versatile coupling reactions with carboxylic acids, ketones, and aldehydes. The Val-Cit dipeptide undergoes proteolytic cleavage within cells, facilitating the release of drug payloads through an elimination mechanism associated with the PAB structure. This compound is ideal for ADC development and other related bioconjugation applications.
Chemical Information
| Catalog Num | A43420 |
|---|---|
| M. Wt | 494.58 |
| Formula | C23H38N6O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2055024-63-8 |
| Synonyms | |
| SMILES | OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCN)=O)=O)=O |
Biological Activity
| Description | NH2-PEG1-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker designed for efficient payload delivery. This reagent features a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group, enabling versatile coupling reactions with carboxylic acids, ketones, and aldehydes. The Val-Cit dipeptide undergoes proteolytic cleavage within cells, facilitating the release of drug payloads through an elimination mechanism associated with the PAB structure. This compound is ideal for ADC development and other related bioconjugation applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
