Product Data Sheet
NH2-PEG4-Val-Cit-PAB-OH
Catalog No. A43425
NH2-PEG4-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker designed for targeted delivery of therapeutic payloads. Its structure includes a primary amine for versatile coupling reactions, a hydrophilic PEG spacer, and a Val-Cit dipeptide that is readily cleaved by cellular proteases, facilitating the release of the drug inside target cells. The PAB moiety enables efficient attachment of reactive groups, enhancing conjugation with drug payloads. This linker is valuable in research applications involving ADC development and optimization, enabling precise targeting in cancer therapy.
Chemical Information
| Catalog Num | A43425 |
|---|---|
| M. Wt | 626.74 |
| Formula | C29H50N6O9 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2055024-61-6 |
| Synonyms | |
| SMILES | NCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C=C1)CO)=O)=O)=O |
Biological Activity
| Description | NH2-PEG4-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker designed for targeted delivery of therapeutic payloads. Its structure includes a primary amine for versatile coupling reactions, a hydrophilic PEG spacer, and a Val-Cit dipeptide that is readily cleaved by cellular proteases, facilitating the release of the drug inside target cells. The PAB moiety enables efficient attachment of reactive groups, enhancing conjugation with drug payloads. This linker is valuable in research applications involving ADC development and optimization, enabling precise targeting in cancer therapy. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
