Product Data Sheet
Mal-amide-PEG8-Val-Cit-PAB-PNP
Catalog No. A43455
Mal-amide-PEG8-Val-Cit-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker that targets thiol groups through its maleimide component, enabling selective labeling of cysteine residues in proteins. This linker incorporates an 8-unit polyethylene glycol (PEG) spacer for improved solubility and a Val-Cit dipeptide that is susceptible to cleavage by cytoplasmic peptidases, facilitating controlled drug release. The PAB and PNP carbonate groups enhance the linker’s reactivity, making it suitable for developing potent and targeted therapeutic agents in cancer research and other applications involving ADCs.
Chemical Information
| Catalog Num | A43455 |
|---|---|
| M. Wt | 1119.17 |
| Formula | C51H74N8O20 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1964490-09-2 |
| Synonyms | |
| SMILES | O=C(C=CC1=O)N1CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(C=C2)COC(OC3=CC=C(C=C3)[N+]([O-])=O)=O)=O)=O)=O)=O |
Biological Activity
| Description | Mal-amide-PEG8-Val-Cit-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker that targets thiol groups through its maleimide component, enabling selective labeling of cysteine residues in proteins. This linker incorporates an 8-unit polyethylene glycol (PEG) spacer for improved solubility and a Val-Cit dipeptide that is susceptible to cleavage by cytoplasmic peptidases, facilitating controlled drug release. The PAB and PNP carbonate groups enhance the linker’s reactivity, making it suitable for developing potent and targeted therapeutic agents in cancer research and other applications involving ADCs. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
