Product Data Sheet
NH2-PEG6-Val-Cit-PAB-OH
Catalog No. A43463
NH2-PEG6-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker that incorporates a primary amine, a PEG spacer, a Val-Cit dipeptide, and a PAB group. This design facilitates the attachment of reactive groups, enabling the conjugation of drug payloads through the benzylic alcohol on the PAB moiety. The primary amine allows for versatile reactions, including coupling with carboxylic acids and reductive aminations. Within cells, the Val-Cit dipeptide is cleaved by proteases, promoting efficient drug release via the elimination mechanism inherent to the PAB structure, thus enhancing therapeutic efficacy in targeted delivery applications.
Chemical Information
| Catalog Num | A43463 |
|---|---|
| M. Wt | 714.85 |
| Formula | C33H58N6O11 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2055024-60-5 |
| Synonyms | |
| SMILES | NCCOCCOCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C=C1)CO)=O)=O)=O |
Biological Activity
| Description | NH2-PEG6-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker that incorporates a primary amine, a PEG spacer, a Val-Cit dipeptide, and a PAB group. This design facilitates the attachment of reactive groups, enabling the conjugation of drug payloads through the benzylic alcohol on the PAB moiety. The primary amine allows for versatile reactions, including coupling with carboxylic acids and reductive aminations. Within cells, the Val-Cit dipeptide is cleaved by proteases, promoting efficient drug release via the elimination mechanism inherent to the PAB structure, thus enhancing therapeutic efficacy in targeted delivery applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
