Product Data Sheet
SN34037
Catalog No. A43601
SN34037 is a selective inhibitor of Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188), which plays a pivotal role in cellular redox balance and glucose metabolism. This compound effectively inhibits the cytotoxic activity of PR-104A in cell lines with high AKR1C3 expression, such as TF1 erythroleukemia cells, while demonstrating minimal impact in Nalm6 pre-B acute lymphoblastic leukemia cells with low AKR1C3 expression. SN34037 can also be utilized for the rapid assessment of AKR1C3 activity via coumberone reduction, making it valuable for research on metabolic pathways and therapeutic interventions targeting AKR1C3.
Chemical Information
| Catalog Num | A43601 |
|---|---|
| M. Wt | 344.24 |
| Formula | C15H19Cl2N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1548116-54-6 |
| Synonyms | |
| SMILES | O=C(N1CCN(CC1)C2=CC=C(C=C2Cl)Cl)N3CCOCC3 |
Biological Activity
| Description | SN34037 is a selective inhibitor of Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188), which plays a pivotal role in cellular redox balance and glucose metabolism. This compound effectively inhibits the cytotoxic activity of PR-104A in cell lines with high AKR1C3 expression, such as TF1 erythroleukemia cells, while demonstrating minimal impact in Nalm6 pre-B acute lymphoblastic leukemia cells with low AKR1C3 expression. SN34037 can also be utilized for the rapid assessment of AKR1C3 activity via coumberone reduction, making it valuable for research on metabolic pathways and therapeutic interventions targeting AKR1C3. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
