Product Data Sheet
M 16209
Catalog No. A43630
M 16209 is an orally active inhibitor of aldose reductase (AR), a key enzyme in the polyol pathway. This compound demonstrates effective inhibition of AR from multiple sources, with IC50 values of 0.12 μM for rat lens AR, 0.24 μM for bovine lens AR, 4.5 μM for bovine kidney AR, 1.2 μM for canine lens AR, and 9.3 μM for human placental AR. M 16209 is valuable for research into metabolic diseases, particularly diabetes, by influencing the glucose metabolic pathway and potentially mitigating complications associated with hyperglycemia.
Chemical Information
| Catalog Num | A43630 |
|---|---|
| M. Wt | 359.15 |
| Formula | C11H7BrN2O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 128851-36-5 |
| Synonyms | |
| SMILES | O=C1NC(CN1S(=O)(C2=C(Br)C3=CC=CC=C3O2)=O)=O |
Biological Activity
| Description | M 16209 is an orally active inhibitor of aldose reductase (AR), a key enzyme in the polyol pathway. This compound demonstrates effective inhibition of AR from multiple sources, with IC50 values of 0.12 μM for rat lens AR, 0.24 μM for bovine lens AR, 4.5 μM for bovine kidney AR, 1.2 μM for canine lens AR, and 9.3 μM for human placental AR. M 16209 is valuable for research into metabolic diseases, particularly diabetes, by influencing the glucose metabolic pathway and potentially mitigating complications associated with hyperglycemia. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
