Product Data Sheet
ARI-809
Catalog No. A43642
ARI-809 is a potent and selective aldose reductase inhibitor, exhibiting an IC50 of 1 nM. By inhibiting aldose reductase, ARI-809 effectively reduces excessive glucose flux through the polyol pathway, resulting in the normalization of elevated sorbitol and fructose levels in diabetic models. This compound demonstrates significant potential in alleviating complications associated with diabetes, such as sorbitol accumulation in lens tissues and elevated urinary albumin excretion. ARI-809 is suitable for use in diabetes-related research applications.
Chemical Information
| Catalog Num | A43642 |
|---|---|
| M. Wt | 324.74 |
| Formula | C13H9ClN2O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 463976-07-0 |
| Synonyms | CP-744809 |
| SMILES | O=C1C=CC(S(=O)(C2=C(C)C3=CC(Cl)=CC=C3O2)=O)=NN1 |
Biological Activity
| Description | ARI-809 is a potent and selective aldose reductase inhibitor, exhibiting an IC50 of 1 nM. By inhibiting aldose reductase, ARI-809 effectively reduces excessive glucose flux through the polyol pathway, resulting in the normalization of elevated sorbitol and fructose levels in diabetic models. This compound demonstrates significant potential in alleviating complications associated with diabetes, such as sorbitol accumulation in lens tissues and elevated urinary albumin excretion. ARI-809 is suitable for use in diabetes-related research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
