Product Data Sheet
AMPK activator 18
Catalog No. A43957
AMPK Activator 18 is a potent allosteric activator of AMPK complexes, particularly those containing the β2 isoform. It effectively activates α2-containing AMPK α2β2γ1 and α2β2γ3 complexes, exhibiting EC50 values of 17.2 nM and 82.1 nM, respectively. This compound stimulates β2-AMPK in cellular contexts and enhances glucose uptake in isolated skeletal muscle. Additionally, AMPK Activator 18 promotes phosphorylation of acetyl-coenzyme A carboxylase (ACC) and AMPK at the α-T172 site, making it a valuable tool for research in type 2 diabetes.
Chemical Information
| Catalog Num | A43957 |
|---|---|
| M. Wt | 471.90 |
| Formula | C26H18ClN3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1364692-88-5 |
| Synonyms | |
| SMILES | O=C(O)C1=CC(OC2=NC3=NC(=C(Cl)C=C3N2)C4=CC=C(C=C4)C5=CC=CC=C5O)=CC=C1C |
Biological Activity
| Description | AMPK Activator 18 is a potent allosteric activator of AMPK complexes, particularly those containing the β2 isoform. It effectively activates α2-containing AMPK α2β2γ1 and α2β2γ3 complexes, exhibiting EC50 values of 17.2 nM and 82.1 nM, respectively. This compound stimulates β2-AMPK in cellular contexts and enhances glucose uptake in isolated skeletal muscle. Additionally, AMPK Activator 18 promotes phosphorylation of acetyl-coenzyme A carboxylase (ACC) and AMPK at the α-T172 site, making it a valuable tool for research in type 2 diabetes. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
