Product Data Sheet
AR-102
Catalog No. A43988
AR-102 is an antibacterial agent that exhibits potent inhibitory activity against Staphylococcus aureus. It demonstrates competitive inhibition of the F98Y mutant dihydrofolate reductase (DHFR) with a Ki value of 0.22 nM. Structural studies have characterized AR-102 as forming a ternary complex with NADPH in both wild-type and TMP-resistant F98Y mutant S. aureus DHFR, making it a valuable compound for research on antibacterial resistance mechanisms.
Chemical Information
| Catalog Num | A43988 |
|---|---|
| M. Wt | 538.69 |
| Formula | C28H42O8S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 955005-63-7 |
| Synonyms | |
| SMILES | O[C@@H](C1=CC2=CC=CC=C2S1)CC[C@@H]3[C@H]([C@H](C[C@H]3O)O)CCCCCCC(OCC(CO)(CO)CO)=O |
Biological Activity
| Description | AR-102 is an antibacterial agent that exhibits potent inhibitory activity against Staphylococcus aureus. It demonstrates competitive inhibition of the F98Y mutant dihydrofolate reductase (DHFR) with a Ki value of 0.22 nM. Structural studies have characterized AR-102 as forming a ternary complex with NADPH in both wild-type and TMP-resistant F98Y mutant S. aureus DHFR, making it a valuable compound for research on antibacterial resistance mechanisms. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
