Product Data Sheet
Hapalindole Q
Catalog No. A44074
Hapalindole Q is a selective YAP1 inhibitor that functions by inducing the degradation of the Hippo pathway transcription factor YAP1 through the chaperone-mediated autophagy (CMA) pathway. With a dissociation constant (Kd) of 9.13 μM, Hapalindole Q effectively hinders Rab7-mediated autophagosome and lysosome fusion, resulting in a decrease in overall autophagy levels while preserving lysosomal function. This compound is relevant for cancer research, particularly in the context of liver and breast cancer investigations.
Chemical Information
| Catalog Num | A44074 |
|---|---|
| M. Wt | 336.49 |
| Formula | C21H24N2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 106928-29-4 |
| Synonyms | |
| SMILES | C[C@](CC[C@H]([C@@H]1C2=CNC3=CC=CC=C32)C(C)=C)([C@@H]1N=C=S)C=C |
Biological Activity
| Description | Hapalindole Q is a selective YAP1 inhibitor that functions by inducing the degradation of the Hippo pathway transcription factor YAP1 through the chaperone-mediated autophagy (CMA) pathway. With a dissociation constant (Kd) of 9.13 μM, Hapalindole Q effectively hinders Rab7-mediated autophagosome and lysosome fusion, resulting in a decrease in overall autophagy levels while preserving lysosomal function. This compound is relevant for cancer research, particularly in the context of liver and breast cancer investigations. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
