Product Data Sheet
BRD5648
Catalog No. A44121
BRD5648 serves as a negative control for the potent GSK-3α inhibitor, BRD0705. This compound selectively targets GSK-3α with an IC50 of 66 nM, demonstrating up to an 8-fold preference over GSK-3β, which has an IC50 of 515 nM. Research applications for BRD5648 include investigations into mechanisms of action for GSK-3 inhibition, particularly in the context of acute myeloid leukemia (AML) and related hematological malignancies.
Chemical Information
| Catalog Num | A44121 |
|---|---|
| M. Wt | 321.42 |
| Formula | C20H23N3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2056261-42-6 |
| Synonyms | (R)-BRD0705 |
| SMILES | O=C1C2=C(N=C3C([C@@]2(CC)C4=CC=CC=C4)=CNN3)CC(C)(C)C1 |
Biological Activity
| Description | BRD5648 serves as a negative control for the potent GSK-3α inhibitor, BRD0705. This compound selectively targets GSK-3α with an IC50 of 66 nM, demonstrating up to an 8-fold preference over GSK-3β, which has an IC50 of 515 nM. Research applications for BRD5648 include investigations into mechanisms of action for GSK-3 inhibition, particularly in the context of acute myeloid leukemia (AML) and related hematological malignancies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
