Product Data Sheet
TPE-MI
Catalog No. A44291
TPE-MI (Tetraphenylethene maleimide) is a fluorogenic dye that serves as a thiol probe for evaluating unfolded protein load and proteostasis in cellular contexts. Its excitation and emission wavelengths at 350 nm and 470 nm respectively enable sensitive detection of proteostasis imbalances in induced pluripotent stem cell models of Huntington’s disease, as well as in cells expressing mutant Huntington exon 1 prior to aggregate formation. Additionally, TPE-MI is valuable for assessing protein damage in studies involving dihydroartemisinin and the malaria parasite Plasmodium falciparum.
Chemical Information
| Catalog Num | A44291 |
|---|---|
| M. Wt | 441.52 |
| Formula | C31H23NO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1245606-71-6 |
| Synonyms | Tetraphenylethene maleimide |
| SMILES | O=C(C=C1)N(C2=CC=C(/C(C3=CC=CC=C3)=C(C4=CC=C(C)C=C4)/C5=CC=CC=C5)C=C2)C1=O |
Biological Activity
| Description | TPE-MI (Tetraphenylethene maleimide) is a fluorogenic dye that serves as a thiol probe for evaluating unfolded protein load and proteostasis in cellular contexts. Its excitation and emission wavelengths at 350 nm and 470 nm respectively enable sensitive detection of proteostasis imbalances in induced pluripotent stem cell models of Huntington’s disease, as well as in cells expressing mutant Huntington exon 1 prior to aggregate formation. Additionally, TPE-MI is valuable for assessing protein damage in studies involving dihydroartemisinin and the malaria parasite Plasmodium falciparum. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
