Product Data Sheet
BG-DBCO
Catalog No. A44366
BG-DBCO is a DBCO-conjugated benzylguanine that serves as an essential intermediate for synthesizing BG-JQ1. This compound forms a complex with SNAP-E3 fusion protein and Ligand-N3, facilitating targeted applications in cellular research. BG-JQ1, derived from the conjugation of BG-DBCO with JQ1-N3-C10, has demonstrated potent inhibitory effects on the growth of small cell carcinoma of the adrenocortical gland when administered alongside SIAH1-SN mRNA. This reagent is invaluable for studies aimed at understanding and targeting cancer cell proliferation pathways.
Chemical Information
| Catalog Num | A44366 |
|---|---|
| M. Wt | 557.60 |
| Formula | C32H27N7O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1820756-74-8 |
| Synonyms | SNAP-DBCO |
| SMILES | NC1=NC2=C(C(OCC3=CC=C(C=C3)CNC(CCC(N4CC5=C(C#CC6=CC=CC=C46)C=CC=C5)=O)=O)=N1)N=CN2 |
Biological Activity
| Description | BG-DBCO is a DBCO-conjugated benzylguanine that serves as an essential intermediate for synthesizing BG-JQ1. This compound forms a complex with SNAP-E3 fusion protein and Ligand-N3, facilitating targeted applications in cellular research. BG-JQ1, derived from the conjugation of BG-DBCO with JQ1-N3-C10, has demonstrated potent inhibitory effects on the growth of small cell carcinoma of the adrenocortical gland when administered alongside SIAH1-SN mRNA. This reagent is invaluable for studies aimed at understanding and targeting cancer cell proliferation pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
