Product Data Sheet
Jatrorrhizine chloride
Catalog No. A45828
Jatrorrhizine chloride is a bioactive alkaloid derived from Coptis chinensis, exhibiting diverse pharmacological properties such as neuroprotection, antimicrobial action, antiplasmodial effects, and antioxidant activity. This compound acts as a potent and selective inhibitor of acetylcholinesterase (AChE) with an IC50 of 872 nM, demonstrating over 115-fold selectivity for butyrylcholinesterase (BuChE). Additionally, Jatrorrhizine chloride inhibits the uptake of serotonin (5-HT) and norepinephrine (NE) through blockade of uptake-2 transporters, making it a valuable tool in neurological and pharmacological research.
Chemical Information
| Catalog Num | A45828 |
|---|---|
| M. Wt | 373.83 |
| Formula | C20H20ClNO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 6681-15-8 |
| Synonyms | |
| SMILES | COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(O)C=C4CC3)C=C2C=C1.[Cl-] |
Biological Activity
| Description | Jatrorrhizine chloride is a bioactive alkaloid derived from Coptis chinensis, exhibiting diverse pharmacological properties such as neuroprotection, antimicrobial action, antiplasmodial effects, and antioxidant activity. This compound acts as a potent and selective inhibitor of acetylcholinesterase (AChE) with an IC50 of 872 nM, demonstrating over 115-fold selectivity for butyrylcholinesterase (BuChE). Additionally, Jatrorrhizine chloride inhibits the uptake of serotonin (5-HT) and norepinephrine (NE) through blockade of uptake-2 transporters, making it a valuable tool in neurological and pharmacological research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
