Product Data Sheet
Syk Inhibitor II
Catalog No. A45840
Syk Inhibitor II is a highly selective, ATP-competitive inhibitor of spleen tyrosine kinase (Syk) with an IC50 of 41 nM. It effectively inhibits 5-hydroxytryptamine (5-HT) release from rat basophilic leukemia (RBL) cells, demonstrating an IC50 of 460 nM. This compound exhibits a lower potency against other kinases, making it a valuable tool for studying Syk-mediated signaling pathways and exploring its potential in anti-allergic research applications.
Chemical Information
| Catalog Num | A45840 |
|---|---|
| M. Wt | 340.30 |
| Formula | C14H15F3N6O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 726695-51-8 |
| Synonyms | |
| SMILES | O=C(C1=CN=C(NCCN)N=C1NC2=CC=CC(C(F)(F)F)=C2)N |
Biological Activity
| Description | Syk Inhibitor II is a highly selective, ATP-competitive inhibitor of spleen tyrosine kinase (Syk) with an IC50 of 41 nM. It effectively inhibits 5-hydroxytryptamine (5-HT) release from rat basophilic leukemia (RBL) cells, demonstrating an IC50 of 460 nM. This compound exhibits a lower potency against other kinases, making it a valuable tool for studying Syk-mediated signaling pathways and exploring its potential in anti-allergic research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
