Product Data Sheet
GR127935 hydrochloride
Catalog No. A45862
GR127935 hydrochloride is a potent antagonist of the 5-HT1D and 5-HT1B receptors, demonstrating pKis of 8.5 for both isoforms. It exhibits a significant 100-fold selectivity for the 5-HT1B and 5-HT1D receptors compared to other serotonin receptor subtypes, including 5-HT1A, 5-HT2A, and 5-HT2C. This compound is valuable for research involving neurological diseases and exploring serotonin receptor dynamics.
Chemical Information
| Catalog Num | A45862 |
|---|---|
| M. Wt | 534.05 |
| Formula | C29H32ClN5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 148642-42-6 |
| Synonyms | |
| SMILES | O=C(C1=CC=C(C2=CC=C(C3=NOC(C)=N3)C=C2C)C=C1)NC4=CC=C(OC)C(N5CCN(C)CC5)=C4.[H]Cl |
Biological Activity
| Description | GR127935 hydrochloride is a potent antagonist of the 5-HT1D and 5-HT1B receptors, demonstrating pKis of 8.5 for both isoforms. It exhibits a significant 100-fold selectivity for the 5-HT1B and 5-HT1D receptors compared to other serotonin receptor subtypes, including 5-HT1A, 5-HT2A, and 5-HT2C. This compound is valuable for research involving neurological diseases and exploring serotonin receptor dynamics. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
