Product Data Sheet
Jatrorrhizine hydroxide
Catalog No. A45901
Jatrorrhizine hydroxide is a bioactive alkaloid derived from Coptis chinensis, primarily known for its neuroprotective, antimicrobial, antiplasmodial, and antioxidant properties. It functions as a potent and orally active inhibitor of acetylcholinesterase (AChE) with an IC50 of 872 nM, exhibiting over 115-fold selectivity for butyrylcholinesterase (BuChE). Additionally, Jatrorrhizine hydroxide inhibits the uptake of serotonin (5-HT) and norepinephrine (NE) through the modulation of uptake-2 transporters, making it valuable for research in neuropharmacology and neurodegenerative disorders.
Chemical Information
| Catalog Num | A45901 |
|---|---|
| M. Wt | 355.38 |
| Formula | C20H21NO5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 483-43-2 |
| Synonyms | |
| SMILES | COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(O)C=C4CC3)C=C2C=C1.[OH-] |
Biological Activity
| Description | Jatrorrhizine hydroxide is a bioactive alkaloid derived from Coptis chinensis, primarily known for its neuroprotective, antimicrobial, antiplasmodial, and antioxidant properties. It functions as a potent and orally active inhibitor of acetylcholinesterase (AChE) with an IC50 of 872 nM, exhibiting over 115-fold selectivity for butyrylcholinesterase (BuChE). Additionally, Jatrorrhizine hydroxide inhibits the uptake of serotonin (5-HT) and norepinephrine (NE) through the modulation of uptake-2 transporters, making it valuable for research in neuropharmacology and neurodegenerative disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
