Product Data Sheet
Spiroxatrine
Catalog No. A45919
Spiroxatrine is a selective dual antagonist of the 5-HT1α and α2-adrenergic receptors, exhibiting Ki values of 3.94 nM for 5-HT1α, 224,000 nM for 5-HT1β, and 118.5 nM for 5-HT2. This compound demonstrates notable sedative effects, making it relevant for research into anxiety and depressive disorders. Spiroxatrine is valuable for studies exploring the modulation of serotonergic and adrenergic signaling pathways.
Chemical Information
| Catalog Num | A45919 |
|---|---|
| M. Wt | 379.45 |
| Formula | C22H25N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1054-88-2 |
| Synonyms | R 5188 |
| SMILES | O=C1NCN(C2=CC=CC=C2)C13CCN(CC4OC5=CC=CC=C5OC4)CC3 |
Biological Activity
| Description | Spiroxatrine is a selective dual antagonist of the 5-HT1α and α2-adrenergic receptors, exhibiting Ki values of 3.94 nM for 5-HT1α, 224,000 nM for 5-HT1β, and 118.5 nM for 5-HT2. This compound demonstrates notable sedative effects, making it relevant for research into anxiety and depressive disorders. Spiroxatrine is valuable for studies exploring the modulation of serotonergic and adrenergic signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
