Product Data Sheet
GR127935
Catalog No. A45937
GR127935 is a selective antagonist for the 5-HT1D and 5-HT1B receptors, exhibiting a pKi of 8.5 for both isoforms. This compound demonstrates a significant 100-fold selectivity for the 5-HT1B and 5-HT1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors. GR127935 is primarily utilized in research focused on neurological disorders, aiding in the exploration of serotonergic signaling pathways.
Chemical Information
| Catalog Num | A45937 |
|---|---|
| M. Wt | 497.59 |
| Formula | C29H31N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 148672-13-3 |
| Synonyms | |
| SMILES | O=C(NC1=CC=C(OC)C(N2CCN(C)CC2)=C1)C3=CC=C(C4=CC=C(C5=NOC(C)=N5)C=C4C)C=C3 |
Biological Activity
| Description | GR127935 is a selective antagonist for the 5-HT1D and 5-HT1B receptors, exhibiting a pKi of 8.5 for both isoforms. This compound demonstrates a significant 100-fold selectivity for the 5-HT1B and 5-HT1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors. GR127935 is primarily utilized in research focused on neurological disorders, aiding in the exploration of serotonergic signaling pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
