Product Data Sheet
Brexpiprazole-d8
Catalog No. A45938
Brexpiprazole-d8 is a deuterium-labeled derivative of Brexpiprazole, an atypical antipsychotic agent. Acting primarily as a partial agonist at the human 5-HT1A and dopamine D2L receptors, it exhibits Ki values of 0.12 nM and 0.3 nM, respectively. Additionally, Brexpiprazole functions as a 5-HT2A receptor antagonist with a Ki of 0.47 nM and exhibits significant antagonistic activity at noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM). This reagent is suitable for various research applications including pharmacological studies and mechanism of action investigations.
Chemical Information
| Catalog Num | A45938 |
|---|---|
| M. Wt | 441.62 |
| Formula | C25H19D8N3O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1427049-21-5 |
| Synonyms | OPC-34712-d8 |
| SMILES | O=C1NC2=C(C=CC(OCCCCN3C([2H])([2H])C([2H])([2H])N(C4=C(C=CS5)C5=CC=C4)C([2H])([2H])C3([2H])[2H])=C2)C=C1 |
Biological Activity
| Description | Brexpiprazole-d8 is a deuterium-labeled derivative of Brexpiprazole, an atypical antipsychotic agent. Acting primarily as a partial agonist at the human 5-HT1A and dopamine D2L receptors, it exhibits Ki values of 0.12 nM and 0.3 nM, respectively. Additionally, Brexpiprazole functions as a 5-HT2A receptor antagonist with a Ki of 0.47 nM and exhibits significant antagonistic activity at noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM). This reagent is suitable for various research applications including pharmacological studies and mechanism of action investigations. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
