Product Data Sheet
SB 206553
Catalog No. A45945
SB 206553 is an inverse agonist of the 5-HT2C receptor, demonstrating significant biological activity with pKi values of 5.6 nM, 7.7 nM, and 7.8 nM for the 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively, in HEK-293 and CHO-K1 cell lines expressing human recombinant receptors. This compound has been shown to attenuate methamphetamine-seeking behavior in rat models. SB 206553 is valuable for research into psychostimulant abuse disorders and the underlying mechanisms of serotonergic signaling.
Chemical Information
| Catalog Num | A45945 |
|---|---|
| M. Wt | 292.34 |
| Formula | C17H16N4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 158942-04-2 |
| Synonyms | |
| SMILES | O=C(N1CCC2=C1C=C3C(N(C)C=C3)=C2)NC4=CC=CN=C4 |
Biological Activity
| Description | SB 206553 is an inverse agonist of the 5-HT2C receptor, demonstrating significant biological activity with pKi values of 5.6 nM, 7.7 nM, and 7.8 nM for the 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively, in HEK-293 and CHO-K1 cell lines expressing human recombinant receptors. This compound has been shown to attenuate methamphetamine-seeking behavior in rat models. SB 206553 is valuable for research into psychostimulant abuse disorders and the underlying mechanisms of serotonergic signaling. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
