Product Data Sheet
Brexpiprazole-d8-1
Catalog No. A45947
Brexpiprazole-d8-1 is a stable isotope-labeled form of Brexpiprazole, an atypical antipsychotic agent. It functions as a partial agonist at the human 5-HT1A and dopamine D2L receptors, exhibiting affinities (Ki values) of 0.12 nM and 0.3 nM, respectively. Additionally, it acts as an antagonist at the 5-HT2A receptor with a Ki of 0.47 nM, and demonstrates potent antagonistic activity at noradrenergic α1B and α2C receptors with Ki values of 0.17 nM and 0.59 nM, respectively. This compound is suited for studies involving neuropharmacology and receptor interaction analysis.
Chemical Information
| Catalog Num | A45947 |
|---|---|
| M. Wt | 441.62 |
| Formula | C25H19D8N3O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1427049-19-1 |
| Synonyms | OPC-34712-d8-1 |
| SMILES | O=C1C=CC2=CC=C(C=C2N1)OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N3CCN(CC3)C4=C5C(SC=C5)=CC=C4 |
Biological Activity
| Description | Brexpiprazole-d8-1 is a stable isotope-labeled form of Brexpiprazole, an atypical antipsychotic agent. It functions as a partial agonist at the human 5-HT1A and dopamine D2L receptors, exhibiting affinities (Ki values) of 0.12 nM and 0.3 nM, respectively. Additionally, it acts as an antagonist at the 5-HT2A receptor with a Ki of 0.47 nM, and demonstrates potent antagonistic activity at noradrenergic α1B and α2C receptors with Ki values of 0.17 nM and 0.59 nM, respectively. This compound is suited for studies involving neuropharmacology and receptor interaction analysis. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
