Product Data Sheet
YM-31636 free base
Catalog No. A45952
YM-31636 free base is a potent and selective agonist of the 5-HT3 receptor, exhibiting a Ki value of 0.2 nM. This compound effectively induces contraction in isolated guinea pig distal colon, suggesting its role in gastrointestinal motility. Additionally, YM-31636 free base demonstrates tachycardia through a relative intrinsic activity of approximately 0.23 in isolated guinea pig right atrium, indicating potential applications in research focusing on constipation and related gastrointestinal disorders.
Chemical Information
| Catalog Num | A45952 |
|---|---|
| M. Wt | 253.32 |
| Formula | C14H11N3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 159081-22-8 |
| Synonyms | |
| SMILES | C1(CC2=NC3=C(S2)CC4=C3C=CC=C4)=CN=CN1 |
Biological Activity
| Description | YM-31636 free base is a potent and selective agonist of the 5-HT3 receptor, exhibiting a Ki value of 0.2 nM. This compound effectively induces contraction in isolated guinea pig distal colon, suggesting its role in gastrointestinal motility. Additionally, YM-31636 free base demonstrates tachycardia through a relative intrinsic activity of approximately 0.23 in isolated guinea pig right atrium, indicating potential applications in research focusing on constipation and related gastrointestinal disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
