Product Data Sheet
Syk Inhibitor II dihydrochloride
Catalog No. A46064
Syk Inhibitor II dihydrochloride is a highly selective, ATP-competitive inhibitor of Spleen Tyrosine Kinase (Syk) with an IC50 of 41 nM. It effectively inhibits 5-HT release from rat basophilic leukemia (RBL) cells, demonstrating an IC50 of 460 nM. This compound exhibits reduced potency against other kinases, making it a valuable tool for research applications in immunology and allergy research, particularly in studies investigating Syk's role in signaling pathways associated with allergic responses.
Chemical Information
| Catalog Num | A46064 |
|---|---|
| M. Wt | 413.23 |
| Formula | C14H17Cl2F3N6O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 227449-73-2 |
| Synonyms | |
| SMILES | O=C(C1=CN=C(NCCN)N=C1NC2=CC=CC(C(F)(F)F)=C2)N.[H]Cl.[H]Cl |
Biological Activity
| Description | Syk Inhibitor II dihydrochloride is a highly selective, ATP-competitive inhibitor of Spleen Tyrosine Kinase (Syk) with an IC50 of 41 nM. It effectively inhibits 5-HT release from rat basophilic leukemia (RBL) cells, demonstrating an IC50 of 460 nM. This compound exhibits reduced potency against other kinases, making it a valuable tool for research applications in immunology and allergy research, particularly in studies investigating Syk's role in signaling pathways associated with allergic responses. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
