Product Data Sheet
Agomelatine-d3
Catalog No. A46068
Agomelatine-d3 is a deuterium-labeled derivative of Agomelatine, which primarily targets MT1 and MT2 melatonin receptors, demonstrating high affinity with Ki values of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2 cells, respectively. Additionally, Agomelatine acts as a selective antagonist of the 5-HT2C receptor with pKi values of 6.4 and 6.2 for native porcine and cloned human receptors, respectively. This stable isotope compound is valuable for pharmacokinetic studies and metabolic research involving melatonergic modulation and serotonin receptor interactions.
Chemical Information
| Catalog Num | A46068 |
|---|---|
| M. Wt | 246.32 |
| Formula | C15H14D3NO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1079389-38-0 |
| Synonyms | S-20098-d3 |
| SMILES | [2H]C([2H])([2H])C(NCCC1=CC=CC2=C1C=C(OC)C=C2)=O |
Biological Activity
| Description | Agomelatine-d3 is a deuterium-labeled derivative of Agomelatine, which primarily targets MT1 and MT2 melatonin receptors, demonstrating high affinity with Ki values of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2 cells, respectively. Additionally, Agomelatine acts as a selective antagonist of the 5-HT2C receptor with pKi values of 6.4 and 6.2 for native porcine and cloned human receptors, respectively. This stable isotope compound is valuable for pharmacokinetic studies and metabolic research involving melatonergic modulation and serotonin receptor interactions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
