Product Data Sheet
JH-131e-153
Catalog No. A46239
JH-131e-153 is a diacylglycerol (DAG)-lactone that functions as a small molecule activator of Munc13-1 by targeting its C1 domain. This compound demonstrates a specific activation sequence for Munc13-1, with a comparative hierarchy of WT>I590≈R592A≈W588A. Its activation profile reveals homology with protein kinase C (PKC), indicating potential cross-functional mechanisms. JH-131e-153 plays a crucial role in modulating neuronal processes and serves as a valuable tool for investigating the underlying mechanisms of neurodegenerative diseases.
Chemical Information
| Catalog Num | A46239 |
|---|---|
| M. Wt | 382.53 |
| Formula | C22H38O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 742104-91-2 |
| Synonyms | |
| SMILES | CC(C)(C)C(OC[C@@](C/C1=C/CC(CC(C)C)CC(C)C)(CO)OC1=O)=O |
Biological Activity
| Description | JH-131e-153 is a diacylglycerol (DAG)-lactone that functions as a small molecule activator of Munc13-1 by targeting its C1 domain. This compound demonstrates a specific activation sequence for Munc13-1, with a comparative hierarchy of WT>I590≈R592A≈W588A. Its activation profile reveals homology with protein kinase C (PKC), indicating potential cross-functional mechanisms. JH-131e-153 plays a crucial role in modulating neuronal processes and serves as a valuable tool for investigating the underlying mechanisms of neurodegenerative diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
