Product Data Sheet
Trovafloxacin mesylate
Catalog No. A46328
Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, demonstrating potent activity against Gram-positive, Gram-negative, and anaerobic pathogens. Additionally, it serves as a selective and orally active inhibitor of the pannexin 1 channel (PANX1), with an IC50 of 4 μM for PANX1 inward current. Unlike other channels, Trovafloxacin mesylate does not affect connexin 43 gap junctions or PANX2, leading to potential therapeutic applications in the regulation of apoptosis by disrupting normal fragmentation of apoptotic cells through PANX1 inhibition.
Chemical Information
| Catalog Num | A46328 |
|---|---|
| M. Wt | 512.46 |
| Formula | C21H19F3N4O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 147059-75-4 |
| Synonyms | |
| SMILES | O=C(C1=CN(C2=CC=C(F)C=C2F)C3=NC(N4C[C@@]5([H])[C@H](N)[C@@]5([H])C4)=C(F)C=C3C1=O)O.CS(=O)(O)=O |
Biological Activity
| Description | Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, demonstrating potent activity against Gram-positive, Gram-negative, and anaerobic pathogens. Additionally, it serves as a selective and orally active inhibitor of the pannexin 1 channel (PANX1), with an IC50 of 4 μM for PANX1 inward current. Unlike other channels, Trovafloxacin mesylate does not affect connexin 43 gap junctions or PANX2, leading to potential therapeutic applications in the regulation of apoptosis by disrupting normal fragmentation of apoptotic cells through PANX1 inhibition. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
