Product Data Sheet
Gramicidin S
Catalog No. A46340
Gramicidin S is a cationic cyclic peptide antibiotic that primarily targets bacterial cell membranes. It exhibits potent antibacterial activity by disrupting membrane integrity and inhibiting critical membrane protein functions, leading to cell death. The compound inserts into the phospholipid bilayer, specifically binding to negatively charged lipids, which interferes with cell division and wall synthesis. Additionally, Gramicidin S has been shown to inhibit ion channels, with IC50 values of 41 μM for Na+/K+-ATPase, 24 μM for tobacco leaf plasma membrane Mg2+/K+-ATPase, and 3 μM for rat heart plasma membrane Ca2+-ATPase, making it a valuable tool for research in microbiology and cell biology.
Chemical Information
| Catalog Num | A46340 |
|---|---|
| M. Wt | 1141.45 |
| Formula | C60H92N12O10 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 113-73-5 |
| Synonyms | Gramicidin soviet |
| SMILES | O=C1N2[C@](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC3=CC=CC=C3)C(=O)N4[C@](C(=O)N[C@@H]([C@@H](C)C)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]1CC5=CC=CC=C5)(CCC4)[H])(CCC2)[H] |
Biological Activity
| Description | Gramicidin S is a cationic cyclic peptide antibiotic that primarily targets bacterial cell membranes. It exhibits potent antibacterial activity by disrupting membrane integrity and inhibiting critical membrane protein functions, leading to cell death. The compound inserts into the phospholipid bilayer, specifically binding to negatively charged lipids, which interferes with cell division and wall synthesis. Additionally, Gramicidin S has been shown to inhibit ion channels, with IC50 values of 41 μM for Na+/K+-ATPase, 24 μM for tobacco leaf plasma membrane Mg2+/K+-ATPase, and 3 μM for rat heart plasma membrane Ca2+-ATPase, making it a valuable tool for research in microbiology and cell biology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
