Product Data Sheet
Lolamicin
Catalog No. A46344
Lolamicin is an orally effective antibiotic that specifically targets the Gram-negative bacterial lipoprotein transport system, particularly the LolCDE complex. By competitively binding to lipoprotein binding sites, it inhibits the transmembrane transport of outer membrane lipoproteins, compromising the integrity of the bacterial outer membrane and resulting in cell death. Lolamicin demonstrates significant bactericidal and antibacterial activity against multidrug-resistant Enterobacteriaceae pathogens, including Escherichia coli and Klebsiella pneumoniae. This reagent is valuable for studying infections such as acute pneumonia and sepsis caused by Gram-negative bacteria.
Chemical Information
| Catalog Num | A46344 |
|---|---|
| M. Wt | 380.44 |
| Formula | C24H20N4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2930690-12-1 |
| Synonyms | |
| SMILES | N#CC1=CC=CC(COC2=CC=CC(C3=NNC=C3C4=CC(C)=NC(C)=C4)=C2)=C1 |
Biological Activity
| Description | Lolamicin is an orally effective antibiotic that specifically targets the Gram-negative bacterial lipoprotein transport system, particularly the LolCDE complex. By competitively binding to lipoprotein binding sites, it inhibits the transmembrane transport of outer membrane lipoproteins, compromising the integrity of the bacterial outer membrane and resulting in cell death. Lolamicin demonstrates significant bactericidal and antibacterial activity against multidrug-resistant Enterobacteriaceae pathogens, including Escherichia coli and Klebsiella pneumoniae. This reagent is valuable for studying infections such as acute pneumonia and sepsis caused by Gram-negative bacteria. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
