Product Data Sheet
PAMAM Dendrimer G0.0 amine (20% in methanol)
Catalog No. A46506
PAMAM Dendrimer G0.0 amine is an antibiotic targeting pore-forming toxins, specifically acting as an antagonist to anthrax toxin protective antigen 63 (PA63, IC50 = 231 nM) and C. botulinum C2 toxin subunit (C2IIa, IC50 = 940 nM). At concentrations of 10 and 20 µM, it demonstrates protective effects against C2 toxin-induced cytotoxicity in HeLa cells. Additionally, this compound acts as a nickel chelator and has been employed in the selective capture and storage of carbon dioxide in gas-feed systems when used in conjunction with polysulfone membrane-bound chitosan. PAMAM Dendrimer G0.0 amine serves as a valuable reagent in research focused on infectious diseases, cancer biology, and drug delivery systems.
Chemical Information
| Catalog Num | A46506 |
|---|---|
| M. Wt | 516.68 |
| Formula | C22H48N10O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 155773-72-1 |
| Synonyms | |
| SMILES | O=C(CCN(CCN(CCC(NCCN)=O)CCC(NCCN)=O)CCC(NCCN)=O)NCCN |
Biological Activity
| Description | PAMAM Dendrimer G0.0 amine is an antibiotic targeting pore-forming toxins, specifically acting as an antagonist to anthrax toxin protective antigen 63 (PA63, IC50 = 231 nM) and C. botulinum C2 toxin subunit (C2IIa, IC50 = 940 nM). At concentrations of 10 and 20 µM, it demonstrates protective effects against C2 toxin-induced cytotoxicity in HeLa cells. Additionally, this compound acts as a nickel chelator and has been employed in the selective capture and storage of carbon dioxide in gas-feed systems when used in conjunction with polysulfone membrane-bound chitosan. PAMAM Dendrimer G0.0 amine serves as a valuable reagent in research focused on infectious diseases, cancer biology, and drug delivery systems. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
