Product Data Sheet
Sulfathiazole-d4
Catalog No. A46515
Sulfathiazole-d4 is a deuterium-labeled variant of Sulfathiazole, which serves as a selective antibiotic with specific endocrine-disrupting properties. It primarily targets the steroidogenic pathway by enhancing the activity of CYP19 in human adrenal cancer cells (H295R) while upregulating mRNA expression of CYP17, CYP19, and 3β-HSD. This compound is instrumental in increasing the production of 17-estradiol (E2) and has been shown to exert endocrine-disrupting effects in aquatic organisms, including species such as the Japanese medaka fish, making it a valuable tool for studies on endocrine disruption and steroid metabolism.
Chemical Information
| Catalog Num | A46515 |
|---|---|
| M. Wt | 259.34 |
| Formula | C9H5D4N3O2S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1020719-89-4 |
| Synonyms | |
| SMILES | O=S(C1=C([2H])C([2H])=C(N)C([2H])=C1[2H])(NC2=NC=CS2)=O |
Biological Activity
| Description | Sulfathiazole-d4 is a deuterium-labeled variant of Sulfathiazole, which serves as a selective antibiotic with specific endocrine-disrupting properties. It primarily targets the steroidogenic pathway by enhancing the activity of CYP19 in human adrenal cancer cells (H295R) while upregulating mRNA expression of CYP17, CYP19, and 3β-HSD. This compound is instrumental in increasing the production of 17-estradiol (E2) and has been shown to exert endocrine-disrupting effects in aquatic organisms, including species such as the Japanese medaka fish, making it a valuable tool for studies on endocrine disruption and steroid metabolism. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
