Product Data Sheet
Cilastatin-15N,d3
Catalog No. A46610
Cilastatin-15N,d3 is a stable isotope-labeled derivative of Cilastatin, specifically incorporating 15N and deuterium. As a reversible, competitive inhibitor of renal dehydropeptidase I, it demonstrates an IC50 of 0.1 μM. Additionally, Cilastatin has been shown to inhibit the bacterial metallob-lactamase enzyme CphA, with an IC50 of 178 μM. This reagent serves as an important tool in antibacterial research and studies involving enzyme inhibition mechanisms.
Chemical Information
| Catalog Num | A46610 |
|---|---|
| M. Wt | 362.46 |
| Formula | C16H23D3N15NO5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2738376-83-3 |
| Synonyms | MK0791-15N,d3 |
| SMILES | O=C(O)/C(NC([C@@H]1C(C)(C)C1)=O)=C/CCCCSC([2H])([2H])C([15NH2])([2H])C(O)=O |
Biological Activity
| Description | Cilastatin-15N,d3 is a stable isotope-labeled derivative of Cilastatin, specifically incorporating 15N and deuterium. As a reversible, competitive inhibitor of renal dehydropeptidase I, it demonstrates an IC50 of 0.1 μM. Additionally, Cilastatin has been shown to inhibit the bacterial metallob-lactamase enzyme CphA, with an IC50 of 178 μM. This reagent serves as an important tool in antibacterial research and studies involving enzyme inhibition mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
