Product Data Sheet
Herbimycin A
Catalog No. A46651
Herbimycin A is an ansamycin antibiotic that serves as a potent inhibitor of Src family kinases. By binding to the SH domain, it effectively inhibits the activity of p60v-src and p210BCR-ABL, highlighting its relevance in cancer research. Additionally, Herbimycin A disrupts Hsp90 function and impedes cellular recovery from heat shock, while also demonstrating antiangiogenic properties in vitro in endothelial cells. This reagent is valuable for studies focusing on cellular stress responses and angiogenesis.
Chemical Information
| Catalog Num | A46651 |
|---|---|
| M. Wt | 574.66 |
| Formula | C30H42N2O9 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 70563-58-5 |
| Synonyms | |
| SMILES | CO[C@H]([C@H](C[C@@H]([C@@H]([C@H](/C=C([C@@H]1OC(N)=O)\C)C)OC)OC)C)C(C(C(NC(/C(C)=C/C=C\[C@@H]1OC)=O)=C2)=O)=CC2=O |
Biological Activity
| Description | Herbimycin A is an ansamycin antibiotic that serves as a potent inhibitor of Src family kinases. By binding to the SH domain, it effectively inhibits the activity of p60v-src and p210BCR-ABL, highlighting its relevance in cancer research. Additionally, Herbimycin A disrupts Hsp90 function and impedes cellular recovery from heat shock, while also demonstrating antiangiogenic properties in vitro in endothelial cells. This reagent is valuable for studies focusing on cellular stress responses and angiogenesis. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
