Product Data Sheet
Thiomarinol A
Catalog No. A46859
Thiomarinol A, a potent antibiotic, primarily targets bacterial isoleucyl-tRNA synthetase (IleRS), particularly in methicillin-resistant Staphylococcus aureus (MRSA). This compound, a hybrid of dithiolopyrrolone and marinolic acid, demonstrates significant antimicrobial activity through a dose-dependent inhibition, with a Kiapp value of 19 nM. Thiomarinol A is valuable for research applications focused on antibiotic development and the study of resistant bacterial strains.
Chemical Information
| Catalog Num | A46859 |
|---|---|
| M. Wt | 640.81 |
| Formula | C30H44N2O9S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 146697-04-3 |
| Synonyms | 4-Hydroxythiomarinol C |
| SMILES | O[C@@H]([C@@]1([H])[C@@H]([C@@H]([C@H](CO1)C/C=C/[C@@H](C)[C@@H](O)C)O)O)/C(C)=C/C(OCCCCCCCC(NC2=C3C(NC2=O)=CSS3)=O)=O |
Biological Activity
| Description | Thiomarinol A, a potent antibiotic, primarily targets bacterial isoleucyl-tRNA synthetase (IleRS), particularly in methicillin-resistant Staphylococcus aureus (MRSA). This compound, a hybrid of dithiolopyrrolone and marinolic acid, demonstrates significant antimicrobial activity through a dose-dependent inhibition, with a Kiapp value of 19 nM. Thiomarinol A is valuable for research applications focused on antibiotic development and the study of resistant bacterial strains. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
