Product Data Sheet
Iturin A-2
Catalog No. A46896
Iturin A-2 is a cyclic lipopeptide antibiotic derived from Bacillus subtilis, demonstrating potent inhibitory activity against the plant pathogenic fungus Penicillium expansum with a minimal inhibitory concentration (MIC) of 8 µg/disk. This compound exhibits cytotoxic effects on various cancer cell lines, including MCF-7, BT474, and HeLa, with IC50 values of 66.81, 95.04, and 77.5 µg/mL, respectively. Additionally, Iturin A-2 effectively reduces lesion areas in southern corn leaf blight caused by Bipolaris maydis in greenhouse studies and decreases disease incidence in field studies at higher concentrations. At 12.5 µg/mL, Iturin A-2 inhibits cell division in isolated fertilized starfish eggs without affecting nuclear division.
Chemical Information
| Catalog Num | A46896 |
|---|---|
| M. Wt | 1043.17 |
| Formula | C48H74N12O14 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 83785-07-3 |
| Synonyms | |
| SMILES | CCCCCCCCCCCC1CC(=O)NC(CC(N)=O)C(=O)NC(Cc2ccc(O)cc2)C(=O)NC(CC(N)=O)C(=O)NC(CCC(N)=O)C(=O)N2CCCC2C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)N1 |
Biological Activity
| Description | Iturin A-2 is a cyclic lipopeptide antibiotic derived from Bacillus subtilis, demonstrating potent inhibitory activity against the plant pathogenic fungus Penicillium expansum with a minimal inhibitory concentration (MIC) of 8 µg/disk. This compound exhibits cytotoxic effects on various cancer cell lines, including MCF-7, BT474, and HeLa, with IC50 values of 66.81, 95.04, and 77.5 µg/mL, respectively. Additionally, Iturin A-2 effectively reduces lesion areas in southern corn leaf blight caused by Bipolaris maydis in greenhouse studies and decreases disease incidence in field studies at higher concentrations. At 12.5 µg/mL, Iturin A-2 inhibits cell division in isolated fertilized starfish eggs without affecting nuclear division. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
