Product Data Sheet
Celastramycin A
Catalog No. A47189
Celastramycin A is an antibiotic derived from Streptomyces MaB-QuH-8, known for its significant antimicrobial activity against a variety of gram-negative bacteria and mycobacteria, with minimum inhibitory concentrations (MICs) ranging from 0.05 to 3.1 μg/ml. This compound exhibits immunosuppressive effects, evidenced by its ability to modulate immune responses in ex vivo Drosophila and human models, demonstrating an IC50 of 0.008 μg/ml through the immune deficiency pathway and inhibiting TNF-α signaling. Additionally, Celastramycin A effectively reduces IL-8 production in human umbilical vein endothelial cells (HUEVCs), with an IC50 of 0.06 μg/ml, making it a valuable tool for research in microbial resistance and immune modulation.
Chemical Information
| Catalog Num | A47189 |
|---|---|
| M. Wt | 390.69 |
| Formula | C17H18Cl3NO3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 188988-62-7 |
| Synonyms | |
| SMILES | O=C(C1=C(O)C(CCCCCC)=CC(Cl)=C1O)C2=CC(Cl)=C(Cl)N2 |
Biological Activity
| Description | Celastramycin A is an antibiotic derived from Streptomyces MaB-QuH-8, known for its significant antimicrobial activity against a variety of gram-negative bacteria and mycobacteria, with minimum inhibitory concentrations (MICs) ranging from 0.05 to 3.1 μg/ml. This compound exhibits immunosuppressive effects, evidenced by its ability to modulate immune responses in ex vivo Drosophila and human models, demonstrating an IC50 of 0.008 μg/ml through the immune deficiency pathway and inhibiting TNF-α signaling. Additionally, Celastramycin A effectively reduces IL-8 production in human umbilical vein endothelial cells (HUEVCs), with an IC50 of 0.06 μg/ml, making it a valuable tool for research in microbial resistance and immune modulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
