Product Data Sheet
Oximidine Ⅲ
Catalog No. A47293
Oximidine III is an antitumor antibiotic that selectively inhibits the growth of 3Y1 rat fibroblast cells, demonstrating significant effects on various tumor-associated genes. It targets both v-H-ras-3Y1 and v-src-3Y1 cells, with IC50 values of 14 nM and 4.5 nM, respectively, while normal 3Y1 cells show an IC50 of 140 nM. Oximidine III effectively halts the cell cycle at the G1 phase in RAS or SRC-activated cells and promotes the expression of p21WAF1, making it valuable for research in cancer biology and therapeutic development.
Chemical Information
| Catalog Num | A47293 |
|---|---|
| M. Wt | 424.45 |
| Formula | C23H24N2O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 664365-72-4 |
| Synonyms | |
| SMILES | CO/N=C/C=C\C(N/C=C/C[C@H]1C[C@@]2([H])[C@](/C=C\C=C\C3=CC=CC(O)=C3C(O1)=O)([H])O2)=O |
Biological Activity
| Description | Oximidine III is an antitumor antibiotic that selectively inhibits the growth of 3Y1 rat fibroblast cells, demonstrating significant effects on various tumor-associated genes. It targets both v-H-ras-3Y1 and v-src-3Y1 cells, with IC50 values of 14 nM and 4.5 nM, respectively, while normal 3Y1 cells show an IC50 of 140 nM. Oximidine III effectively halts the cell cycle at the G1 phase in RAS or SRC-activated cells and promotes the expression of p21WAF1, making it valuable for research in cancer biology and therapeutic development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
