Product Data Sheet
Neospiramycin I
Catalog No. A47361
Neospiramycin I is a macrolide antibiotic that targets bacterial ribosomes, inhibiting protein synthesis. It demonstrates significant antibacterial activity against macrolide-sensitive strains of Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 3.12 µg/mL, and exhibits effectiveness against various Gram-positive bacteria, including Bacillus cereus and Bacillus subtilis, along with Gram-negative bacteria such as Escherichia coli and Klebsiella pneumoniae, at MIC values ranging from 0.2 to 50 µg/mL. In vivo, Neospiramycin I protects mice in a type III S. pneumoniae infection model, with an effective dose 50 (ED50) of 399.8 mg/kg, making it a valuable tool for studies on bacterial resistance and antibiotic efficacy.
Chemical Information
| Catalog Num | A47361 |
|---|---|
| M. Wt | 698.88 |
| Formula | C36H62N2O11 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 70253-62-2 |
| Synonyms | |
| SMILES | O=CC[C@@H](C[C@H]([C@H](/C=C/C=C/C[C@H](OC(C[C@H]([C@@H]1OC)O)=O)C)O[C@@H]2O[C@@H]([C@H](CC2)N(C)C)C)C)[C@@H]1O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)C)O)N(C)C)O |
Biological Activity
| Description | Neospiramycin I is a macrolide antibiotic that targets bacterial ribosomes, inhibiting protein synthesis. It demonstrates significant antibacterial activity against macrolide-sensitive strains of Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 3.12 µg/mL, and exhibits effectiveness against various Gram-positive bacteria, including Bacillus cereus and Bacillus subtilis, along with Gram-negative bacteria such as Escherichia coli and Klebsiella pneumoniae, at MIC values ranging from 0.2 to 50 µg/mL. In vivo, Neospiramycin I protects mice in a type III S. pneumoniae infection model, with an effective dose 50 (ED50) of 399.8 mg/kg, making it a valuable tool for studies on bacterial resistance and antibiotic efficacy. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
