Product Data Sheet
AM-112
Catalog No. A47525
AM-112 is a potent β-lactamase inhibitor that targets class A, C, and D β-lactamase enzymes, demonstrating IC50 values as low as 0.0002 μg/mL. Its mechanism involves the inhibition of PBP2, a penicillin-binding protein in E. coli, thereby protecting Ceftazidime from enzymatic hydrolysis and enhancing its antibacterial activity against Gram-negative bacteria, enterococci, and staphylococci. AM-112 exhibits favorable pharmacokinetic properties and acid-base stability, making it a valuable tool for research into bacterial infections.
Chemical Information
| Catalog Num | A47525 |
|---|---|
| M. Wt | 298.34 |
| Formula | C14H22N2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 414858-51-8 |
| Synonyms | |
| SMILES | [C@H](C)(O)[C@@]1([C@@]2(N(C(C(O)=O)=C(C(CCCN)(C)C)O2)C1=O)[H])[H] |
Biological Activity
| Description | AM-112 is a potent β-lactamase inhibitor that targets class A, C, and D β-lactamase enzymes, demonstrating IC50 values as low as 0.0002 μg/mL. Its mechanism involves the inhibition of PBP2, a penicillin-binding protein in E. coli, thereby protecting Ceftazidime from enzymatic hydrolysis and enhancing its antibacterial activity against Gram-negative bacteria, enterococci, and staphylococci. AM-112 exhibits favorable pharmacokinetic properties and acid-base stability, making it a valuable tool for research into bacterial infections. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
