Product Data Sheet
2(5H)-Furanone
Catalog No. A47995
2(5H)-Furanone, also known as γ-Crotonolactone, is an endogenous metabolite that mimics N-acyl homoserine lactone signals, targeting LuxR homologs to disrupt quorum sensing-mediated gene regulation. This compound effectively inhibits quorum sensing associated with AHLs of varying acyl chain lengths and reduces biofilm formation in environmental *Aeromonas hydrophila* strains on polystyrene surfaces. Additionally, 2(5H)-Furanone has been shown to suppress spike-and-wave discharges in rat models of generalized absence seizures, demonstrating selective efficacy against this type of seizure. Its diverse biological activities make it a valuable reagent for research into bacterial infections and seizure disorders.
Chemical Information
| Catalog Num | A47995 |
|---|---|
| M. Wt | 84.07 |
| Formula | C4H4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 497-23-4 |
| Synonyms | γ-Crotonolactone |
| SMILES | O=C1OCC=C1 |
Biological Activity
| Description | 2(5H)-Furanone, also known as γ-Crotonolactone, is an endogenous metabolite that mimics N-acyl homoserine lactone signals, targeting LuxR homologs to disrupt quorum sensing-mediated gene regulation. This compound effectively inhibits quorum sensing associated with AHLs of varying acyl chain lengths and reduces biofilm formation in environmental *Aeromonas hydrophila* strains on polystyrene surfaces. Additionally, 2(5H)-Furanone has been shown to suppress spike-and-wave discharges in rat models of generalized absence seizures, demonstrating selective efficacy against this type of seizure. Its diverse biological activities make it a valuable reagent for research into bacterial infections and seizure disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
