Product Data Sheet
8-O-Acetylharpagide
Catalog No. A48111
8-O-Acetylharpagide is an iridoid glycoside compound that primarily targets anti-aging and anti-cancer pathways. At low doses, it demonstrates significant anti-aging properties, while high doses induce apoptosis and necrosis in cancer cells, effectively downregulating anti-apoptotic proteins such as Akt, p-Akt, and Bcl-2. Metabolism studies indicate that 8-O-acetylharpagide undergoes processes like demethylation, hydrolysis, and glucuronidation in rats, leading to the formation of active metabolites that attenuate the AKT/NF-κB/MMP9 signaling axis. Additionally, it exerts vasoconstrictive effects through the activation of vascular α-adrenoceptors, further contributing to its biological activity.
Chemical Information
| Catalog Num | A48111 |
|---|---|
| M. Wt | 406.38 |
| Formula | C17H26O11 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 6926-14-3 |
| Synonyms | |
| SMILES | O[C@@]([C@@H]1O)(C=CO2)[C@]([C@](OC(C)=O)(C)C1)([H])[C@@H]2O[C@]([C@@H]([C@@H](O)[C@@H]3O)O)([H])O[C@@H]3CO |
Biological Activity
| Description | 8-O-Acetylharpagide is an iridoid glycoside compound that primarily targets anti-aging and anti-cancer pathways. At low doses, it demonstrates significant anti-aging properties, while high doses induce apoptosis and necrosis in cancer cells, effectively downregulating anti-apoptotic proteins such as Akt, p-Akt, and Bcl-2. Metabolism studies indicate that 8-O-acetylharpagide undergoes processes like demethylation, hydrolysis, and glucuronidation in rats, leading to the formation of active metabolites that attenuate the AKT/NF-κB/MMP9 signaling axis. Additionally, it exerts vasoconstrictive effects through the activation of vascular α-adrenoceptors, further contributing to its biological activity. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
