Product Data Sheet
Apalcillin
Catalog No. A48986
Apalcillin is a bacterial inhibitor designed to target and disrupt the activity of various gram-negative bacteria, particularly those that produce β-lactamase. In combination with Ro 48-1220, a β-lactamase inhibitor, Apalcillin exhibits broad-spectrum activity, effectively inhibiting strains such as Moraxella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae, with minimum inhibitory concentrations as low as 11 μg/mL. This combination also shows significant effectiveness against Pseudomonas aeruginosa and Stenotrophomonas maltophilia at even lower MICs (0.25 to 4 μg/mL). However, its efficacy against certain gram-positive organisms remains limited, making it a valuable tool for research on β-lactamase resistance.
Chemical Information
| Catalog Num | A48986 |
|---|---|
| M. Wt | 521.55 |
| Formula | C25H23N5O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 63469-19-2 |
| Synonyms | PC-904 |
| SMILES | O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](NC(C3=C(O)C4=NC=CC=C4N=C3)=O)C5=CC=CC=C5)=O)N1C2=O)O |
Biological Activity
| Description | Apalcillin is a bacterial inhibitor designed to target and disrupt the activity of various gram-negative bacteria, particularly those that produce β-lactamase. In combination with Ro 48-1220, a β-lactamase inhibitor, Apalcillin exhibits broad-spectrum activity, effectively inhibiting strains such as Moraxella catarrhalis, Haemophilus influenzae, and Neisseria gonorrhoeae, with minimum inhibitory concentrations as low as 11 μg/mL. This combination also shows significant effectiveness against Pseudomonas aeruginosa and Stenotrophomonas maltophilia at even lower MICs (0.25 to 4 μg/mL). However, its efficacy against certain gram-positive organisms remains limited, making it a valuable tool for research on β-lactamase resistance. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
