Product Data Sheet
ABT-255 hydrochloride
Catalog No. A49660
ABT-255 hydrochloride is an orally active antibacterial agent targeting Mycobacterium tuberculosis. It demonstrates potent in vitro activity with a minimum inhibitory concentration (MIC) ranging from 0.016 to 0.031 μg/mL against both drug-susceptible and resistant strains, including those resistant to Rifampin and Ethambutol. Additionally, ABT-255 hydrochloride exhibits efficacy against Gram-positive and Gram-negative bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Escherichia coli, effectively reducing viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice. This compound is valuable for research applications focused on pulmonary tuberculosis.
Chemical Information
| Catalog Num | A49660 |
|---|---|
| M. Wt | 421.89 |
| Formula | C21H25ClFN3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 181141-52-6 |
| Synonyms | |
| SMILES | O=C(O)C1=CC(C2CC2)=C3C(C)=C(C(F)=CN3C1=O)N4C[C@]([H])(CCCN5)[C@@]5([H])C4.Cl |
Biological Activity
| Description | ABT-255 hydrochloride is an orally active antibacterial agent targeting Mycobacterium tuberculosis. It demonstrates potent in vitro activity with a minimum inhibitory concentration (MIC) ranging from 0.016 to 0.031 μg/mL against both drug-susceptible and resistant strains, including those resistant to Rifampin and Ethambutol. Additionally, ABT-255 hydrochloride exhibits efficacy against Gram-positive and Gram-negative bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Escherichia coli, effectively reducing viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice. This compound is valuable for research applications focused on pulmonary tuberculosis. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
