Product Data Sheet
Prothionamide-d5
Catalog No. A49721
Prothionamide-d5 is a deuterium-labeled analog of Prothionamide, a thioamide antibacterial agent that plays a critical role in combating tuberculosis and leprosy. The compound acts as a substrate for the uptake transporter OCT1 and forms a covalent adduct with NAD, which is a potent inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae's InhA enzyme. Prothionamide demonstrates significant antibacterial activity, effectively inhibiting Mycobacterium tuberculosis with a minimum inhibitory concentration (MIC) of approximately 0.5 µg/mL. This reagent is essential for research applications focused on understanding the mechanisms of action and treatment strategies for mycobacterial infections.
Chemical Information
| Catalog Num | A49721 |
|---|---|
| M. Wt | 185.30 |
| Formula | C9H7D5N2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1330261-26-1 |
| Synonyms | Protionamide-d5 |
| SMILES | S=C(C1=CC(CC([2H])([2H])C([2H])([2H])[2H])=NC=C1)N |
Biological Activity
| Description | Prothionamide-d5 is a deuterium-labeled analog of Prothionamide, a thioamide antibacterial agent that plays a critical role in combating tuberculosis and leprosy. The compound acts as a substrate for the uptake transporter OCT1 and forms a covalent adduct with NAD, which is a potent inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae's InhA enzyme. Prothionamide demonstrates significant antibacterial activity, effectively inhibiting Mycobacterium tuberculosis with a minimum inhibitory concentration (MIC) of approximately 0.5 µg/mL. This reagent is essential for research applications focused on understanding the mechanisms of action and treatment strategies for mycobacterial infections. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
