Product Data Sheet
Steffimycin B
Catalog No. A49927
Steffimycin B is an anthracycline bacterial metabolite derived from Streptomyces, possessing a primary mechanism of DNA binding through preferential intercalation at cytosine and guanine-rich regions. It exhibits significant cytotoxicity against various cell lines, including MCF-7, KB, NCI-H187, and Vero cells, with IC50 values of 3.5, 6.75, 3.28, and 10.5 μM, respectively. Furthermore, Steffimycin B demonstrates potent antimicrobial activity against Mycobacterium tuberculosis (MIC=5.2 nM), Bacillus cereus (MIC=1.56 μg/mL), and Plasmodium falciparum (IC50=2.19 μM), making it a valuable compound for research in cancer and infectious diseases.
Chemical Information
| Catalog Num | A49927 |
|---|---|
| M. Wt | 588.56 |
| Formula | C29H32O13 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 54526-94-2 |
| Synonyms | NSC 204855; U 40615 |
| SMILES | OC1=C(C(C2=C3O)=O)C(C(C2=CC(OC)=C3)=O)=CC(C4=O)=C1[C@H]([C@@H]([C@](O)4C)OC)O[C@H](O[C@H]5C)[C@@H]([C@@H]([C@H]5OC)O)OC |
Biological Activity
| Description | Steffimycin B is an anthracycline bacterial metabolite derived from Streptomyces, possessing a primary mechanism of DNA binding through preferential intercalation at cytosine and guanine-rich regions. It exhibits significant cytotoxicity against various cell lines, including MCF-7, KB, NCI-H187, and Vero cells, with IC50 values of 3.5, 6.75, 3.28, and 10.5 μM, respectively. Furthermore, Steffimycin B demonstrates potent antimicrobial activity against Mycobacterium tuberculosis (MIC=5.2 nM), Bacillus cereus (MIC=1.56 μg/mL), and Plasmodium falciparum (IC50=2.19 μM), making it a valuable compound for research in cancer and infectious diseases. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
