Product Data Sheet
Neoaureothin
Catalog No. A49958
Neoaureothin is a bacterial metabolite derived from Streptomyces that functions as an androgen receptor (AR) antagonist. It effectively inhibits the binding of dihydrotestosterone (DHT) to ARs, demonstrating an IC50 of 13 μM, and significantly reduces DHT-induced prostate-specific antigen expression in LNCaP cells with an IC50 of 1.75 nM. Additionally, Neoaureothin exhibits cytotoxic effects on A549, HCT116, and HepG2 cell lines with IC50 values of 34.3, 47, and 37.2 μg/mL, respectively. It also displays potent nematocidal activity against B. xylophilus, with an LC50 of 0.84 μg/mL, and enhances the survival of P. densiflora trees infected with this nematode.
Chemical Information
| Catalog Num | A49958 |
|---|---|
| M. Wt | 477.55 |
| Formula | C28H31NO6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 59795-94-7 |
| Synonyms | NSC 260179; Spectinabilin |
| SMILES | CC(C1=O)=C([C@@](OC/2)([H])CC2=C\C(C)=C\C(C)=C\C(C)=C\C(C=C3)=CC=C3[N+]([O-])=O)OC(OC)=C1C |
Biological Activity
| Description | Neoaureothin is a bacterial metabolite derived from Streptomyces that functions as an androgen receptor (AR) antagonist. It effectively inhibits the binding of dihydrotestosterone (DHT) to ARs, demonstrating an IC50 of 13 μM, and significantly reduces DHT-induced prostate-specific antigen expression in LNCaP cells with an IC50 of 1.75 nM. Additionally, Neoaureothin exhibits cytotoxic effects on A549, HCT116, and HepG2 cell lines with IC50 values of 34.3, 47, and 37.2 μg/mL, respectively. It also displays potent nematocidal activity against B. xylophilus, with an LC50 of 0.84 μg/mL, and enhances the survival of P. densiflora trees infected with this nematode. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
