Product Data Sheet
Antibacterial agent 327
Catalog No. A49963
Antibacterial agent 327 is a potent inhibitor of Staphylococcus aureus DNA gyrase, demonstrating an IC50 of 0.28 μM against supercoiling activity. It additionally inhibits ATPase activities of both DNA gyrase and Topoisomerase IV, with IC50 values of 0.43 μM and 0.73 μM, respectively, while also affecting Topoisomerase IV decatenation activity (IC50: 2.31 μM). This compound effectively inhibits Clostridioides difficile and methicillin-resistant Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 0.78 μg/mL for both, and shows an MIC50 of 0.78 μg/mL against Escherichia coli. Antibacterial agent 327 is valuable for research focused on bacterial resistance and DNA topology.
Chemical Information
| Catalog Num | A49963 |
|---|---|
| M. Wt | 832.23 |
| Formula | C34H42ClN3O17S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1311163-39-9 |
| Synonyms | |
| SMILES | CC(O[C@H]([C@H]([C@@H](O[C@@H]1COC(C)=O)NC(N/N=C/C2=CC=C(C=C2)Cl)=S)OC(C)=O)[C@@H]1O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)COC(C)=O)OC(C)=O)OC(C)=O)OC(C)=O)=O |
Biological Activity
| Description | Antibacterial agent 327 is a potent inhibitor of Staphylococcus aureus DNA gyrase, demonstrating an IC50 of 0.28 μM against supercoiling activity. It additionally inhibits ATPase activities of both DNA gyrase and Topoisomerase IV, with IC50 values of 0.43 μM and 0.73 μM, respectively, while also affecting Topoisomerase IV decatenation activity (IC50: 2.31 μM). This compound effectively inhibits Clostridioides difficile and methicillin-resistant Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 0.78 μg/mL for both, and shows an MIC50 of 0.78 μg/mL against Escherichia coli. Antibacterial agent 327 is valuable for research focused on bacterial resistance and DNA topology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
