Product Data Sheet
NBTI 5463
Catalog No. A50118
NBTI 5463 is an inhibitor of bacterial type II topoisomerases, specifically targeting topoisomerase II. This compound exhibits potent antibacterial activity by inhibiting GyrA and TopoIV in Pseudomonas aeruginosa and Escherichia coli. By binding to topoisomerase II, NBTI 5463 disrupts DNA cleavage and religation, thereby obstructing bacterial DNA replication and transcription. This compound holds promise for advancing research on Gram-negative bacterial infections.
Chemical Information
| Catalog Num | A50118 |
|---|---|
| M. Wt | 478.54 |
| Formula | C25H30N6O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1227303-03-8 |
| Synonyms | |
| SMILES | N[C@H]([C@@]1([H])CC[C@@H](CC1)NCC2=CC=C(OCC(N3)=O)C3=N2)CN4C5=CC(OC)=CN=C5C=CC4=O |
Biological Activity
| Description | NBTI 5463 is an inhibitor of bacterial type II topoisomerases, specifically targeting topoisomerase II. This compound exhibits potent antibacterial activity by inhibiting GyrA and TopoIV in Pseudomonas aeruginosa and Escherichia coli. By binding to topoisomerase II, NBTI 5463 disrupts DNA cleavage and religation, thereby obstructing bacterial DNA replication and transcription. This compound holds promise for advancing research on Gram-negative bacterial infections. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
