Product Data Sheet
LasB-IN-3
Catalog No. A50360
LasB-IN-3 is a selective inhibitor targeting the LasB protease of Pseudomonas aeruginosa, exhibiting an IC50 value of 8.5 nM for the wild-type enzyme and 58.9 nM for the Met128Val mutant. This compound interacts with the active site of LasB, coordinating zinc ions and establishing hydrogen bonds and CH-π interactions, thereby effectively inhibiting proteolytic activity. LasB-IN-3 has demonstrated potential to enhance survival rates in murine models of LasB-induced acute lung injury, making it a valuable tool for investigating Pseudomonas aeruginosa infections.
Chemical Information
| Catalog Num | A50360 |
|---|---|
| M. Wt | 381.79 |
| Formula | C18H21ClNO4P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2762675-42-1 |
| Synonyms | |
| SMILES | O=C(NC1=CC=C(C=C1)C2=CC=C(C=C2)Cl)C(CC(C)C)P(O)(O)=O |
Biological Activity
| Description | LasB-IN-3 is a selective inhibitor targeting the LasB protease of Pseudomonas aeruginosa, exhibiting an IC50 value of 8.5 nM for the wild-type enzyme and 58.9 nM for the Met128Val mutant. This compound interacts with the active site of LasB, coordinating zinc ions and establishing hydrogen bonds and CH-π interactions, thereby effectively inhibiting proteolytic activity. LasB-IN-3 has demonstrated potential to enhance survival rates in murine models of LasB-induced acute lung injury, making it a valuable tool for investigating Pseudomonas aeruginosa infections. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
