Product Data Sheet
Reveromycin C
Catalog No. A50601
Reveromycin C is a polyketide compound originally derived from Streptomyces, exhibiting significant antifungal activity against Candida albicans, with minimum inhibitory concentrations of 2.0 μg/mL at pH 3 and above 500 μg/mL at pH 7.4. It inhibits EGF-induced mitogenic activity in Balb/MK mouse epidermal cells and effectively reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells with an EC50 of 1.58 μg/mL. Additionally, Reveromycin C suppresses the proliferation of KB cells and K562 human chronic myelogenous leukemia cells, both with an IC50 of 2.0 μg/mL, making it a valuable tool for cancer research and antifungal studies.
Chemical Information
| Catalog Num | A50601 |
|---|---|
| M. Wt | 674.82 |
| Formula | C37H54O11 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 144860-69-5 |
| Synonyms | |
| SMILES | O=C(O[C@@]1(CCC(C)C)[C@H](/C=C/C(C)=C/C(O)=O)O[C@]2(O[C@H](C/C=C(C)/C=C/[C@H](O)[C@@H](C)/C=C/C(O)=O)[C@@H](C)CC2)CC1)CCC(O)=O |
Biological Activity
| Description | Reveromycin C is a polyketide compound originally derived from Streptomyces, exhibiting significant antifungal activity against Candida albicans, with minimum inhibitory concentrations of 2.0 μg/mL at pH 3 and above 500 μg/mL at pH 7.4. It inhibits EGF-induced mitogenic activity in Balb/MK mouse epidermal cells and effectively reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells with an EC50 of 1.58 μg/mL. Additionally, Reveromycin C suppresses the proliferation of KB cells and K562 human chronic myelogenous leukemia cells, both with an IC50 of 2.0 μg/mL, making it a valuable tool for cancer research and antifungal studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
